Ritonavir or lopinavir/ritonavir significantly raise plasma concentrations of oxycodone in healthful human volunteers because of inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin tremendously reduces plasma concentrations of oxycodone on account of robust induction of CYP3A4.Opioids which include oxycodone hydrochloride may well influence th